L6 LINK is a powerful proprietary connection developed by Line 6 to enable easy one-cable connectivity between a variety of Line 6 products. It passes both audio and control data via a single cable connection, and the resulting operation allows users to receive many incredible advantages. Currently POD HD300, HD400 and HD500 guitar multi-effect pedals, and DT50 amplifiers use L6 LINK.

L6 LINK uses a single XLR-type cable to send pristine digital audio in one direction (i.e. from a POD HD500 to a DT50) and control information in two directions (i.e. between a POD HD500 and a DT50). When you connect a POD HD multi-effect pedal to a DT50 guitar amplifier via L6 LINK, turning a tone knob on one will affect the tone of the other.

Since all "control information" (tone knob settings, amp component settings, etc) pass back and forth between the POD HD and DT50, you can control your rig from your amp or your multi-effect and save those settings to a preset in the POD HD for instant recall.

Each POD HD multi-effect pedal can support up to four DT50 amps, but in different ways.

POD HD500 supports four independent channels of audio, all of which can be routed independently to separate DT50 amps. (This makes it possible to create elaborate combinations such as a "wet/dry/wet" rig - one "dry" amp in the center and two "wet" amps left and right with stereo effects.)